One charming option is The Atheneum (1000 Brush Ave., 313/962-2323, www.atheneumsuites.com , $150–299 d), downtown’s best all-suite hotel. Located in the heart of Greektown , it borrows classical motifs from the surrounding neighborhood in its 174 luxury suites, all with separate living rooms, marble bathrooms, high-speed Internet access, and other convenient amenities.
Another unique choice is the Detroit Marriott at the Renaissance Center (GM Renaissance Center, 313/568-8000, www.marriott.com , $229–249 d), which provides terrific views of the Detroit River as well as easy access to the RenCen’s  shops and restaurants.
For traditional chain lodgings, consider the pet-friendly Hilton Garden Inn (351 Gratiot Ave., 313/967-0900, www.hiltongardeninn.com , $170–209 d), located only a block from Comerica Park and Ford Field.
You might also try Courtyard Detroit Downtown (333 E. Jefferson Ave., 313/222-7700, www.marriott.com , $179–219 d), with 260 oversized rooms, an extensive health club, an enormous indoor pool, and an outdoor aboveground tennis court/running track that offers terrific views of the city’s surrounding vintage architecture.