Feel like part of Knoxville’s  downtown renaissance at Cook Loft (722 S. Gay St., 865/637-8108, www.cookloft.com , $450–500), an urban guesthouse and event venue. Skylights, hardwood floors, high ceilings, exposed-brick walls, large windows, and sleek lines bring the loft concept to life. Two bedrooms and a spacious living room invite you to relax and spread out. The kitchen is well furnished with restaurant-grade appliances, but you probably won’t be doing much cooking with all the great restaurants in your backyard. Weekly rates ($2,100) are also available.