The Book Eddy (2537 Chapman Hwy., 865/573-9959) is an above-average used-book store, with a notable collection of local books and collector’s editions. It is located a half-mile south of the Henley Street Bridge in a nondescript shopping plaza.
Another option for used books is McKay’s (230 Papermill Place Way, 865/588-0331), a warehouse-sized bookstore that is well organized and well loved by readers of all stripes.
The closest new book store to downtown Knoxville [1] is Barnes and Noble (8029 Kingston Pk., 865/670-0773), located next to West Town Mall.
Links:
[1] http://www.moon.com/destinations/tennessee/knoxville