Looking like Frank Lloyd Wright parachuted into a 300-year-old plantation and got to work, The Inn at Middleton Place (4290 Ashley River Rd., 843/556-0500, www.theinnatmiddletonplace.com , $215–285) is one of Charleston ’s most unique lodgings—and not only because it’s on the grounds of the historic and beautiful Middleton Place Plantation . The four connected buildings comprising over 50 guest rooms are modern, yet deliberately blend in with the forested, neutral-colored surroundings. The spacious rooms have that same woody minimalism, with excellent fireplaces, spacious Euro-style baths, and huge, floor-to-ceiling windows overlooking the grounds and the river.
Guests also have full access to the rest of the gorgeous Middleton grounds. The only downside is that you’re a lengthy drive from the peninsula and all its attractions, restaurants, and nightlife. While those who need constant stimulation will be disappointed in the deep quietude here, nature-lovers and those in search of peace and quiet will find this almost paradise. And don’t worry about food—the excellent Middleton Place Restaurant  is open for lunch and dinner.