One of the more unique events in Charleston [1] is the Southeastern Wildlife Exposition (various venues, 843/723-1748, www.sewe.com [2], $12.50/day, $30/three days, children 12 and under free). For the last quarter century, the Wildlife Expo has brought together hundreds of artists and exhibitors to showcase just about any kind of naturally themed art you can think of, in over a dozen galleries and venues all over downtown. Kids will enjoy the live animals on hand as well.
Links:
[1] http://www.moon.com/destinations/charleston-savannah/charleston
[2] http://www.sewe.com