Most South Rim [1] sights are located along Hermit Road and Desert View Drive [2], about 35 miles one-way. In between these two scenic routes is Grand Canyon Village [3], best explored on foot.
Sights are arranged in the order that visitors see them arriving from the South Entrance Station [4].
Links:
[1] http://www.moon.com/destinations/grand-canyon/the-south-rim
[2] http://www.moon.com/destinations/grand-canyon/the-south-rim/exploring-the-south-rim/driving-tours
[3] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/historic-grand-canyon-village
[4] http://www.moon.com/destinations/grand-canyon/the-south-rim/exploring-the-south-rim
[5] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/mather-point
[6] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/yavapai-observation-station
[7] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/park-headquarters-and-the-shrine-the-ages
[8] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/bright-angel-trail
[9] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/trailview-overlooks
[10] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/maricopa-point
[11] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/powell-memorial
[12] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/hopi-point
[13] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/mohave-point
[14] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/the-abyss
[15] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/pima-point
[16] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/hermits-rest
[17] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/yaki-point
[18] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/grandview-point
[19] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/tusayan-ruins-and-museum
[20] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/lipan-point
[21] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/desert-view-watchtower
[22] http://www.moon.com/destinations/grand-canyon/the-south-rim/sights/imax-theater