TNM&O/Greyhound (800/231-2222, www.greyhound.com ), the local Greyhound affiliate, connects New Mexico with adjacent states and Mexico—along either I-40 or I-25. Coming from elsewhere in the Southwest, you may want to investigate El Paso–Los Angeles  Limousine Express (915/532-4061 in El Paso, 626/442-1945 in Los Angeles ), the biggest operator of bargain bus service for the Mexican immigrant population—its route runs east–west from El Paso to Los Angeles  but also connects Denver and Albuquerque . It’s both less expensive and more comfortable than TNM&O, but it helps to have some basic Spanish when calling.
Arriving by car is very straightforward: I-40 and I-25 cross in the center of Albuquerque ; I-25 runs straight north to Santa Fe . Two scenic but well-traveled roads run between Santa Fe  and Taos  (take the low road, Highway 68, in winter to avoid snow closures).