Laugh it up in the Gaslamp Quarter [1]! The John Lovitz Comedy Club (Fourth and Island Sts., 866/468-3399, www.thejonlovitzcomedyclub.com [2]) has comics making with the funny most every night of the week. Come out to see major stars you’ll recognize from TV and film, or up-and-coming comics from the showcase specials on Comedy Central.
As a part of the Aubergine complex, the John Lovitz Comedy Club offers far better dining options than the average comedy venue. (Think sushi rather than nachos.) This makes getting yourself to the two-item (food or drink) minimum an easy prospect.
Links:
[1] http://www.moon.com/destinations/california/san-diego/sights/downtown/gaslamp-quarter
[2] http://www.thejonlovitzcomedyclub.com