For a sweet, affordable little Castro [1] inn experience, try the Castillo Inn (48 Henry St., 800/865-5112, $95). With only four rooms and shared baths, you’ll imagine you’ve found a family pension in Tuscany transported to San Francisco [2]. In the midst of the Castro, you’ve got all sorts of queer-life entertainment options only a short stroll way.
Links:
[1] http://www.moon.com/destinations/california/san-francisco-and-the-bay-area/sights/mission-and-castro
[2] http://www.moon.com/destinations/california/san-francisco-and-the-bay-area