Two weeks is just about enough time to see the highlights of Panama [1], including the Panama Canal [2], Panama City [3], the western highlands [4] and both Pacific and Atlantic tropical beaches.
To truly touch on every part of Panama worth visiting, including the Caribbean forts [5], the Darién [6], and the Azuero Peninsula [7], requires at least three weeks, and even then only if one has the cash and inclination to do a fair amount of flying. Four weeks is a more reasonable estimate.
Arrive at Tocumen International Airport and transfer to a hotel in Panama City.
Visit the ruins of Panamá la Vieja [8], go for a walking tour of Casco Viejo [9], and have dinner in one of Panama City’s elegant international restaurants.
Begin your visit to the Panama Canal [2] by exploring the townsites of Balboa [10] and Ancón [11], where a hint of the well-ordered life of the former Canal Zone [12] lives on.
Tour Miraflores Locks [13], perhaps stopping for lunch on the balcony of the visitors center, where one can watch ships transit while dining. Be sure to pass by the impressive Gaillard Cut [13], where canal builders cleaved the mountains of the Continental Divide in two.
Make at least a brief stop to see the wildlife at Gamboa [14] and Parque Nacional Soberanía [15], a true tropical rainforest just a short drive from downtown Panama City. End the day with a ramble along the Amador Causeway [16], a good place to stop for a drink as the Panama City skyline lights up across the bay.
Fly off for a few days of Caribbean sun and sea. Choose between one of two stunning tropical archipelagos: the booming bohemia of Bocas del Toro [17] or the more rustic but culturally fascinating attractions of Kuna Yala [18]; those with a few more days can visit both.
The best way to explore Kuna Yala is from the deck of a hired yacht; those on a limited budget can stay in simple Kuna hotels and get around by motorboat. This is a place for snorkeling off remote cays, walks through traditional island villages, and forest hikes to powerful waterfalls and sacred cemeteries on the mainland.
Head for the highlands of western Panama [4]. Visit the garden town of Boquete [19], famous throughout Panama for its flowers, oranges, and rainbows. Go on a hike up Panama’s tallest peak, Volcan Barú [20], or just admire it from a distance.
To see how the Pacific side of the isthmus compares with the Caribbean, head back down the mountain to the Golfo de Chiriquí [21]. The area around the fishing village of Boca Brava is a gateway to the islands of two national parks, Parque Nacional Marino Golfo de Chiriquí [22] and Parque Nacional Coiba [23], which offer world-class diving. Cool little hotels for every budget are springing up around Boca Brava.
Head back to Panama City [3] by land or air for last-minute shopping, sightseeing, and a farewell dinner.
Transfer to Tocumen International Airport for the flight home.
Links:
[1] http://www.moon.com/destinations/panama
[2] http://www.moon.com/destinations/panama/panama-canal
[3] http://www.moon.com/destinations/panama/panama-city
[4] http://www.moon.com/destinations/panama/western-highlands
[5] http://www.moon.com/destinations/panama/panama-canal/colon/sights/area-protegida-san-lorenzo
[6] http://www.moon.com/destinations/panama/the-darien
[7] http://www.moon.com/destinations/panama/the-azuero-peninsula
[8] http://www.moon.com/destinations/panama/panama-city/sights/panama-la-vieja
[9] http://www.moon.com/destinations/panama/panama-city/sights/casco-viejo
[10] http://www.moon.com/destinations/panama/panama-canal/the-former-canal-zone/sights/balboa
[11] http://www.moon.com/destinations/panama/panama-canal/the-former-canal-zone/sights/cerro-ancon
[12] http://www.moon.com/destinations/panama/panama-canal/the-former-canal-zone
[13] http://www.moon.com/destinations/panama/panama-canal/the-former-canal-zone/sights/pacific-side-locks
[14] http://www.moon.com/destinations/panama/panama-canal/gamboa
[15] http://www.moon.com/destinations/panama/panama-canal/gamboa/sights/parque-nacional-soberania
[16] http://www.moon.com/destinations/panama/panama-canal/the-former-canal-zone/sights/amador-causeway
[17] http://www.moon.com/destinations/panama/bocas-del-toro
[18] http://www.moon.com/destinations/panama/kuna-yala
[19] http://www.moon.com/destinations/panama/western-highlands/boquete
[20] http://www.moon.com/destinations/panama/western-highlands/boquete/sights/parque-nacional-volcan-baru
[21] http://www.moon.com/destinations/panama/western-highlands/golfo-de-chiriqui
[22] http://www.moon.com/destinations/panama/western-highlands/golfo-de-chiriqui/parque-nacional-marino-golfo-de-chiriqui
[23] http://www.moon.com/destinations/panama/western-highlands/golfo-de-chiriqui/parque-nacional-coiba