A block east of the Plaza de Armas, Gran Hotel Don Luis (Quillota 146, tel. 065/259001, fax 065/259005, www.hoteldonluis.cl [1], US$106–115 s or d) is a quality choice.
Gran Hotel Don Vicente (Antonio Varas 447, tel. 065/432900, fax 065/437699, www.granhoteldonvicente.cl [2], US$96/135 s/d) is a traditional downtown favorite.
Links:
[1] http://www.hoteldonluis.cl
[2] http://www.granhoteldonvicente.cl