Santa Cruz de Cana [1]: Cana is the most remote part of Panama, and one of the most beautiful, with extensive trails through pristine foothills, up to a cool cloud forest, and around the jungle-choked remains of an old mining camp. It’s also one of the world’s top birding destinations.
Pirre Station [2]: This is a relatively accessible entrance to the fabled Parque Nacional Darién, Central America’s grandest tropical forest.
Punta Patiño Nature Reserve [3]: Patiño is the largest private nature reserve in the country, and the most comfortable place from which to visit the coast and rivers bordering the Golfo de San Miguel.
Mogue [4]: This is the best bet for those who’d like to spend the night in an Emberá village.
Bahía de Piñas [5]: Considered by many the best deep-sea fishing destination on the planet, the Piñas area also has stunning forests, colorful villages, and the only luxury hotel in the Darién.
Links:
[1] http://www.moon.com/destinations/panama/the-darien/parque-nacional-darien/santa-cruz-de-cana
[2] http://www.moon.com/destinations/panama/the-darien/parque-nacional-darien/pirre-station
[3] http://www.moon.com/destinations/panama/the-darien/coastal-and-upriver-darien/punta-patino-nature-reserve
[4] http://www.moon.com/destinations/panama/the-darien/coastal-and-upriver-darien/mogue
[5] http://www.moon.com/destinations/panama/the-darien/coastal-and-upriver-darien/bahia-de-pinas