Santa Cruz de Cana : Cana is the most remote part of Panama, and one of the most beautiful, with extensive trails through pristine foothills, up to a cool cloud forest, and around the jungle-choked remains of an old mining camp. It’s also one of the world’s top birding destinations.
Pirre Station : This is a relatively accessible entrance to the fabled Parque Nacional Darién, Central America’s grandest tropical forest.
Punta Patiño Nature Reserve : Patiño is the largest private nature reserve in the country, and the most comfortable place from which to visit the coast and rivers bordering the Golfo de San Miguel.
Mogue : This is the best bet for those who’d like to spend the night in an Emberá village.
Bahía de Piñas : Considered by many the best deep-sea fishing destination on the planet, the Piñas area also has stunning forests, colorful villages, and the only luxury hotel in the Darién.