Chile has a handful of border crossings from Peru and Bolivia, and many from Argentina, but relatively few have regular public transportation. Some crossings are seasonal, especially in the high Andes and Patagonia, and others have limited hours.

Bad weather can close the passes across the Andes from Bolivia and Argentina at times, but many stay open all year. In addition to the Peruvian crossing from Tacna to Arica, all-year crossings include the Bolivian routes from La Paz to Arica, from Oruro to Iquique, Uyuni to Calama, and Uyuni to San Pedro de Atacama.

From Argentina, all-year routes include Salta and Jujuy to San Pedro de Atacama and Calama; the Los Libertadores tunnel between Mendoza and Santiago; the San Martín de los Andes to Temuco route via Paso de Mamuil Malal (Paso Tromen to Argentines); the Bariloche-Osorno highway; and the bus-boat shuttle from Bariloche to Puerto Varas.

There are many Patagonian crossings. Those open all year include the road from Esquel (local buses only) to Futaleufú and Chaitén; Comodoro Rivadavia to Coyhaique via Río Mayo; Los Antiguos to Chile Chico; El Calafate to Puerto Natales via Río Turbio; Río Gallegos to Punta Arenas; and Ushuaia and Río Grande to Punta Arenas.